Weight Loss

Well-Being/ Functional Medicine

Weight Loss

GLP-1 receptor agonists (GLP-1RAs) are a class of drugs that can help with weight loss. They mimic the action of glucagon-like peptide 1 (GLP-1), a hormone that helps regulate blood sugar and insulin levels, and promotes feelings of fullness. GLP-1RAs are approved for treating diabetes, obesity, and overweight people with cardiovascular disease. They are also becoming popular for weight loss, with some people taking them off-label.

Here are some things to know about GLP-1RAs and weight loss:

How they work

GLP-1RAs help with weight loss by:

  • Slowing the movement of food from the stomach to the small intestine
  • Causing the body to produce more insulin when blood sugar rises after eating
  • Curbing hunger

Facial changes

Faster weight loss can lead to facial changes, such as:

  • A hollowed look to the face
  • Changes in the size of the lips, cheeks, and chin
  • Wrinkles on the face
  • Sunken eyes
  • Sagging jowls around the jaw and neck

Effectiveness

Tirzepatide and semaglutide are generally considered the most effective GLP-1RAs for weight loss.

Side effects

Common side effects include nausea, vomiting, diarrhea, and headache. More serious side effects are also possible.

Time to see results

Significant weight loss is usually observed around 12 weeks, but it can take up to 17 weeks to reach the final maintenance dose.